About Dr. Mohamed El Hachmi

Cardiogeneticist, researcher, and advocate for precision medicine in inherited cardiac disorders.

Biography

Dr. Mohamed El Hachmi is a cardiogeneticist- Genetic Counsellor with dual PhDs from Sapienza University of Rome and Paris Cité University. He specializes in the diagnosis, management, and research of inherited cardiac disorders, with particular focus on hypertrophic cardiomyopathy, vascular Ehlers-Danlos syndrome, and cardiac amyloidosis.

Dr. El Hachmi's journey in medicine began in Belgium at UCL. Driven by a fascination with the genetic underpinnings of disease, he pursued specialized training in genetic counseling at the University of Siena and biotechnology at the University of Perugia in Italy.

His groundbreaking work in cardiogenetics has led to significant advancements in the understanding and treatment of inherited cardiac disorders. As cardiogeneticist at Hôpital Européen Georges Pompidou in Paris and Cochin Hopital, he established protocols for genetic testing and precision medicine approaches that have improved outcomes for patients with rare cardiac conditions.

Currently, Dr. El Hachmi serves on the Executive Board of the European Board of Medical Genetics, where he contributes to setting standards for genetic medicine practice across Europe. He maintains an active research program focusing on translating genetic discoveries into clinical applications, always with the goal of improving patient care through personalized approaches.

His clinical philosophy centers on combining scientific rigor with compassionate patient care, ensuring that complex genetic information is communicated effectively to empower patients and families in their healthcare decisions.

Academic Background

2022-2025

PhD in Molecular Medicine

Sapienza University of Rome, Italy

Dissertation: "Genetic Determinants of Left Ventricular Remodeling in Cardiomyopathies"

2022-2025

PhD in Cardiology & Epidemiology

Paris Cité University, France

Dissertation: "Precision Medicine Approaches in Inherited Cardiovascular Diseases"

2019-2021

MSc in Biotechnology

University of Perugia, Italy

2013-2015

MSc in Genetic Counseling

University of Siena, Italy

2011-

Faculty of Medicine and Surgery

Université catholique de Louvain (UCL), Belgium

Professional Experience

2022-Present

Executive Board Member (Treasurer)

European Board of Medical Genetics (EBMG)

Contributing to the development of standards and certification for genetic healthcare professionals across Europe. Involved in establishing continuing education requirements and competency assessment.

2025-

Cardiogeneticist

Hôpital Européen Georges Pompidou (HEGP), Paris, France

Led the cardiogenetics clinic specializing in the diagnosis and management of inherited cardiac disorders. Established protocols for genetic testing and counseling for families affected by cardiomyopathies and channelopathies.

2020-Present

Research Supervisor

Precision Medicine Laboratory, University of Perugia, Italy

Supervising doctoral and post-doctoral researchers in projects focused on translational genomics in cardiovascular medicine. Leading collaborations with international research groups.

Clinical Expertise

Dr. El Hachmi combines cutting-edge genetic technology with compassionate patient care to provide comprehensive diagnosis and management of inherited cardiac disorders. His approach focuses on translating complex genetic information into practical clinical decisions that improve patient outcomes.

Genetic Diagnosis

Dr. El Hachmi specializes in the genetic diagnosis of inherited cardiac disorders, utilizing the latest sequencing technologies and interpretation methodologies. His approach includes:

  • Comprehensive genetic testing for cardiomyopathies (HCM, DCM, ARVC, ALVC)
  • Specialized genetic analysis for vascular Ehlers-Danlos syndrome (vEDS)
  • Genetic screening for cardiac amyloidosis (ATTR)
  • Detection of genetic modifiers that influence disease expression
  • Integration of genetic findings with clinical data for accurate diagnosis

Familial Screening and Counseling

Inherited cardiac disorders affect entire families. Dr. El Hachmi provides comprehensive family-based care including:

  • Cascade genetic screening of family members
  • Age-appropriate clinical surveillance protocols
  • Specialized genetic counseling for reproductive planning
  • Psychological support and adaptation strategies
  • Multilingual counseling sessions for international families

Precision Treatments

Dr. El Hachmi specializes in applying genetic information to guide precision treatment approaches, including:

  • Gene-specific treatment selection for optimal outcomes
  • Clinical eligibility assessment for novel targeted therapies
  • Personalized risk stratification for sudden cardiac death
  • Combination therapy protocols for vascular Ehlers-Danlos syndrome
  • Ongoing monitoring and treatment adjustment based on genetic profile

Technical Expertise

Next Generation Sequencing (NGS)

  • Targeted gene panels for cardiomyopathies and channelopathies
  • Whole Exome Sequencing (WES) for complex cases
  • Whole Genome Sequencing (WGS) for research applications
  • Optimized sequencing protocols for difficult genetic regions

Bioinformatics Genomic Analysis

  • Pipeline development for variant calling and filtering
  • Structural variant detection algorithms
  • Copy number variation analysis
  • Integration of multi-omics data for complex phenotypes

Variant Interpretation

  • ACMG/AMP guidelines for variant classification
  • Functional validation of novel variants
  • In silico prediction tools for variant pathogenicity
  • Database curation and variant reclassification

Clinical Risk Assessment

  • Development of genetic risk scores
  • Integration of clinical and genetic data for prognosis
  • Sudden cardiac death risk stratification
  • Family-based penetrance assessment

Contact Information

Email: mohamed.elhachmi@aphp.fr

Languages

  • 🇮🇹 Italian Native
  • 🇫🇷 French Fluent
  • Arabic Fluent
  • English Fluent

Interested in a Research Collaboration?

Dr. El Hachmi is actively seeking collaborators for multicenter studies in cardiogenetics.

Learn More

Schedule a Consultation

Dr. El Hachmi provides specialized consultations for patients with known or suspected inherited cardiac disorders. Referrals from cardiologists and primary care physicians are welcome.

Book an Appointment